Endocrine Abstracts

Adiponectin, the most abundant peptide hormone secreted from adipose tissue, has been negatively correlated with obesity and can induce varying responses on bone. There are significant discrepancies in the published data, showing increased, decreased or no effects on bone turnover.We investigated the effects of adiponectin on the human osteosarcoma cell line Saos-2. After culture with varying concentrations of adiponectin (10–100 nM), supernatants w...

Prostaglandin (PG) E2 has been implicated in benign and neoplastic endometrial pathologies. PGE2 exerts its function by coupling to 4 subtypes of G protein coupled receptors (EP1-EP4). Recently a role for the EP2 receptor in angiogenesis has been established. This study investigated signal transduction and vascular endothelial growth factor (VEGF) expression by the EP2 receptor in Ishikawa endometrial epithelial cells. Ishikawa cells were stably transfect...

Introduction: Adverse drug reactions (ADRs) are a significant cause of morbidity in childhood. We undertook a prospective study to investigate ADRs causing admission to a UK paediatric hospital: this report focuses on corticosteroids (CS).Methods: Three investigators assessed all acute admissions over a 1 year period and identified ADRs by cross-referencing clinical presentations to known ADR profiles using a standardised causality tool.<p class="abs...